Passive immunization of Pacific herring against viral hemorrhagic septicemia.
Journal of Aquatic Animal Health
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Abstract
The plasma of Pacific herring Clupea pallasii that survived laboratory-induced viral hemorrhagic septicemia (VHS) epizootics contained humoral substances that, when injected into naive animals, conferred passive immunity against the disease. Among groups exposed to viral hemorrhagic septicemia virus (VHSV), injection of donor plasma from VHS survivors resulted in significantly greater survival (50%) and significantly lower tissue titers (1.5 x 10(5) plaque-forming units [PFU]/g) than the injection of plasma from VHSV-naive donors (6% survival; 3.7 x 10(6) PFU/g). Additionally, the magnitude of the protective immune response increased during the postexposure period; plasma that was collected from survivors at 123 d postexposure (931 degree-days) provided greater protection than plasma collected from survivors at 60 d postexposure (409 degree-days). These results provide proof of concept that the VHSV exposure history of Pacific herring populations can be determined post hoc; furthermore, the results can be used as the foundation for developing additional high-throughput diagnostic techniques that may be effective at quantifying herd immunity and forecasting the potential for future VHS epizootics in populations of wild Pacific herring.
Suggested Citation
Hershberger, P., Gregg, J., Grady, C., LaPatra, S., Winton, J., 2011, Passive immunization of Pacific herring against viral hemorrhagic septicemia.: Journal of Aquatic Animal Health, v. 23, no. 3, p. 140-147, https://doi.org/10.1080/08997659.2011.616838.
| Publication type | Article |
|---|---|
| Publication Subtype | Journal Article |
| Title | Passive immunization of Pacific herring against viral hemorrhagic septicemia. |
| Series title | Journal of Aquatic Animal Health |
| DOI | 10.1080/08997659.2011.616838 |
| Volume | 23 |
| Issue | 3 |
| Publication Date | September 30, 2011 |
| Year Published | 2011 |
| Language | English |
| Publisher | Taylor and Francis |
| Contributing office(s) | Western Fisheries Research Center |
| Description | 8 p. |
| Larger Work Type | Article |
| Larger Work Subtype | Journal Article |
| Larger Work Title | Journal of Aquatic Animal Health |
| First page | 140 |
| Last page | 147 |