Further development of raccoon poxvirus-vectored vaccines against plague (Yersinia pestis)
Vaccine
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Abstract
In previous studies, we demonstrated protection against plague in mice and prairie dogs using a raccoon pox (RCN) virus-vectored vaccine that expressed the F1 capsular antigen of Yersinia pestis. In order to improve vaccine efficacy, we have now constructed additional RCN-plague vaccines containing two different forms of the lcrV (V) gene, including full-length (Vfull) and a truncated form (V307). Mouse challenge studies with Y. pestis strain CO92 showed that vaccination with a combination of RCN-F1 and the truncated V construct (RCN-V307) provided the greatest improvement (P = 0.01) in protection against plague over vaccination with RCN-F1 alone. This effect was mediated primarily by anti-F1 and anti-V antibodies and both contributed independently to increased survival of vaccinated mice.
Suggested Citation
Rocke, T.E., Iams, K.P., Dawe, S., Smith, S., Williamson, J.L., Heisey, D.M., and Osorio, J.E., 2009, Further development of raccoon poxvirus-vectored vaccines against plague (Yersinia pestis): Vaccine, v. 28, no. 2, p. 338-344, https://doi.org/10.1016/j.vaccine.2009.10.043.
| Publication type | Article |
|---|---|
| Publication Subtype | Journal Article |
| Title | Further development of raccoon poxvirus-vectored vaccines against plague (Yersinia pestis) |
| Series title | Vaccine |
| DOI | 10.1016/j.vaccine.2009.10.043 |
| Volume | 28 |
| Issue | 2 |
| Year Published | 2009 |
| Language | English |
| Publisher | Elsevier |
| Contributing office(s) | National Wildlife Health Center |
| Description | 7 p. |
| First page | 338 |
| Last page | 344 |