Fish T cells: recent advances through genomics
Developmental and Comparative Immunology
Links
- More information: Publisher Index Page (via DOI)
- Download citation as: RIS | Dublin Core
Abstract
This brief review is intended to provide a concise overview of the current literature concerning T cells, advances in identifying distinct T cell functional subsets, and in distinguishing effector cells from memory cells. We compare and contrast a wealth of recent progress made in T cell immunology of teleost, elasmobranch, and agnathan fish, to knowledge derived from mammalian T cell studies. From genome studies, fish clearly have most components associated with T cell function and we can speculate on the presence of putative T cell subsets, and the ability to detect their differentiation to form memory cells. Some recombinant proteins for T cell associated cytokines and antibodies for T cell surface receptors have been generated that will facilitate studying the functional roles of teleost T cells during immune responses. Although there is still a long way to go, major advances have occurred in recent years for investigating T cell responses, thus phenotypic and functional characterization is on the near horizon.
| Publication type | Article |
|---|---|
| Publication Subtype | Journal Article |
| Title | Fish T cells: recent advances through genomics |
| Series title | Developmental and Comparative Immunology |
| DOI | 10.1016/j.dci.2011.03.004 |
| Volume | 35 |
| Issue | 12 |
| Year Published | 2011 |
| Language | English |
| Publisher | Elsevier |
| Contributing office(s) | Western Fisheries Research Center |
| Description | 14 p. |
| Larger Work Type | Article |
| Larger Work Subtype | Journal Article |
| Larger Work Title | Developmental and Comparative Immunology |
| First page | 1282 |
| Last page | 1295 |
| Google Analytic Metrics | Metrics page |