Fish T cells: recent advances through genomics
Developmental and Comparative Immunology
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Abstract
This brief review is intended to provide a concise overview of the current literature concerning T cells, advances in identifying distinct T cell functional subsets, and in distinguishing effector cells from memory cells. We compare and contrast a wealth of recent progress made in T cell immunology of teleost, elasmobranch, and agnathan fish, to knowledge derived from mammalian T cell studies. From genome studies, fish clearly have most components associated with T cell function and we can speculate on the presence of putative T cell subsets, and the ability to detect their differentiation to form memory cells. Some recombinant proteins for T cell associated cytokines and antibodies for T cell surface receptors have been generated that will facilitate studying the functional roles of teleost T cells during immune responses. Although there is still a long way to go, major advances have occurred in recent years for investigating T cell responses, thus phenotypic and functional characterization is on the near horizon.
Suggested Citation
Laing, K.J., Hansen, J.D., 2011, Fish T cells: recent advances through genomics: Developmental and Comparative Immunology, v. 35, no. 12, p. 1282-1295, https://doi.org/10.1016/j.dci.2011.03.004.
| Publication type | Article |
|---|---|
| Publication Subtype | Journal Article |
| Title | Fish T cells: recent advances through genomics |
| Series title | Developmental and Comparative Immunology |
| DOI | 10.1016/j.dci.2011.03.004 |
| Volume | 35 |
| Issue | 12 |
| Year Published | 2011 |
| Language | English |
| Publisher | Elsevier |
| Contributing office(s) | Western Fisheries Research Center |
| Description | 14 p. |
| Larger Work Type | Article |
| Larger Work Subtype | Journal Article |
| Larger Work Title | Developmental and Comparative Immunology |
| First page | 1282 |
| Last page | 1295 |