Expression kinetics of key genes in the early innate immune response to Great Lakes viral hemorrhagic septicemia virus IVb infection in yellow perch (Perca flavescens)
Links
- More information: Publisher Index Page (via DOI)
- Download citation as: RIS | Dublin Core
Abstract
The recently discovered strain of viral hemorrhagic septicemia virus, VHSV-IVb, represents an example of the introduction of an extremely pathogenic rhabdovirus capable of infecting a wide variety of new fish species in a new host-environment. The goal of the present study was to delineate the expression kinetics of key genes in the innate immune response relative to the very early stages of VHSV-IVb infection using the yellow perch (Perca flavescens) as a model. Administration of VHSV-IVb by IP-injection into juvenile yellow perch resulted in 84% cumulative mortality, indicating their high susceptibility to this disease. In fish sampled in the very early stages of infection, a significant up-regulation of Mx gene expression in the liver, as well as IL-1β and SAA activation in the head kidney, spleen, and liver was directly correlated to viral load. The potential down-regulation of Mx in the hematopoietic tissues, head kidney and spleen, may represent a strategy utilized by the virus to increase replication.
Suggested Citation
Olson, W., Emmenegger, E., Glenn, J., Simchick, C., Winton, J., Goetz, F., 2013, Expression kinetics of key genes in the early innate immune response to Great Lakes viral hemorrhagic septicemia virus IVb infection in yellow perch (Perca flavescens): Developmental and Comparative Immunology, v. 41, no. 1, p. 11-19, https://doi.org/10.1016/j.dci.2013.03.012.
| Publication type | Article |
|---|---|
| Publication Subtype | Journal Article |
| Title | Expression kinetics of key genes in the early innate immune response to Great Lakes viral hemorrhagic septicemia virus IVb infection in yellow perch (Perca flavescens) |
| Series title | Developmental and Comparative Immunology |
| DOI | 10.1016/j.dci.2013.03.012 |
| Volume | 41 |
| Issue | 1 |
| Year Published | 2013 |
| Language | English |
| Publisher | Elsevier |
| Contributing office(s) | Western Fisheries Research Center |
| Description | 9 p. |
| First page | 11 |
| Last page | 19 |
| Online Only (Y/N) | N |
| Additional Online Files (Y/N) | N |