Discharge and salinity were measured along the southwest and the southeast coast of Florida in Everglades National Park (ENP) within several rivers and creeks from 1996 through 2008. Data were collected using hydro-acoustic instruments and continuous water-quality monitors at fixed monitoring stations. Water flowed through ENP within two distinct drainage basins; specifically, Shark Slough and Taylor Slough. Discharge to the southwest coast through Shark Slough was substantially larger than discharge to the southeast coast through Taylor Slough. Correlation analysis between coastal flows and regulated flows at water-management structures upstream from ENP suggests rainfall has a larger impact on discharge through Shark Slough than releases from the S-12 water management structures. In contrast, flow releases from water management structures upstream from Taylor Slough appear to be more closely related to discharge along the southeast coast. Salinity varied within a wide range (0 to 50 parts per thousand) along both coastlines. Periods of hypersalinity were greater along the southeast coast due to shallow compartmentalized basins within Florida Bay, which restrict circulation.