A One Health approach that achieves optimal outcomes requires that nontraditional partners come to a common table to identify solutions that transcend organization-specific mandates. This collaboration requires individuals to go beyond their accustomed comfort zones and function on teams with partners who very likely come from unfamiliar organizational, disciplinary, and even national cultures. Each participant represents a separate mandate and an individual corporate culture and values, and each potentially communicates in agency-specific or industry-prescribed cultural terms that may be foreign to the rest of the team. A recent review paper reports that such interdisciplinary teams are most likely to succeed when they have a unified task and a shared goal and values, and when personal relationships are developed from a foundation of trust and respect (1).