Experimental infection of meadow voles (Microtus pennsylvanicus) with sheep scrapie

Canadian Journal of Veterinary Research
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Meadow voles (Microtus pennsylvanicus) are permissive to chronic wasting disease (CWD) infection, but their susceptibility to other transmissible spongiform encephalopathies (TSEs) is poorly characterized. In this initial study, we intracerebrally challenged 6 meadow voles with 2 isolates of sheep scrapie. Three meadow voles acquired a TSE after the scrapie challenge and an extended incubation period. The glycoform profile of proteinase K-resistant prion protein (PrP(res)) in scrapie-sick voles remained similar to the sheep inocula, but differed from that of voles clinically affected by CWD. Vacuolization patterns and disease-associated prion protein (PrP(Sc)) deposition were generally similar in all scrapie-affected voles, except in the hippocampus, where PrP(Sc) staining varied markedly among the animals. Our results demonstrate that meadow voles can acquire a TSE after intracerebral scrapie challenge and that this species could therefore prove useful for characterizing scrapie isolates.

Publication type Article
Publication Subtype Journal Article
Title Experimental infection of meadow voles (Microtus pennsylvanicus) with sheep scrapie
Series title Canadian Journal of Veterinary Research
Volume 79
Issue 1
Year Published 2015
Language English
Publisher Canadian Veterinary Medical Association
Publisher location Ottawa
Contributing office(s) National Wildlife Health Center
Description 6 p.
First page 68
Last page 73
Online Only (Y/N) N
Additional Online Files (Y/N) N
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