Discovery of a novel hepatovirus (Phopivirus of seals) related to human hepatitis A virus
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Abstract
Describing the viral diversity of wildlife can provide interesting and useful insights into the natural history of established human pathogens. In this study, we describe a previously unknown picornavirus in harbor seals (tentatively named phopivirus) that is related to human hepatitis A virus (HAV). We show that phopivirus shares several genetic and phenotypic characteristics with HAV, including phylogenetic relatedness across the genome, a specific and seemingly quiescent tropism for hepatocytes, structural conservation in a key functional region of the type III internal ribosomal entry site (IRES), and a codon usage bias consistent with that of HAV.
| Publication type | Article |
|---|---|
| Publication Subtype | Journal Article |
| Title | Discovery of a novel hepatovirus (Phopivirus of seals) related to human hepatitis A virus |
| Series title | mBio |
| DOI | 10.1128/mBio.01180-15 |
| Volume | 6 |
| Issue | 4 |
| Year Published | 2015 |
| Language | English |
| Publisher | American Society for Microbiology |
| Contributing office(s) | National Wildlife Health Center |
| Description | e01180-15, 10 p. |
| Online Only (Y/N) | N |
| Additional Online Files (Y/N) | N |