The Semidi segment of the Alaska convergent margin appears capable of generating a giant tsunami like the one produced along the nearby Unimak segment in 1946. Reprocessed legacy seismic reflection data and a compilation of multibeam bathymetric surveys reveal structures that could generate such a tsunami. A 200 km long ridge or escarpment with crests >1 km high is the surface expression of an active out-of-sequence fault zone, recently referred to as a splay fault. Such faults are potentially tsunamigenic. This type of fault zone separates the relatively rigid rock of the margin framework from the anelastic accreted sediment prism. Seafloor relief of the ridge exceeds that of similar age accretionary prism ridges indicating preferential slip along the splay fault zone. The greater slip may derive from Quaternary subduction of the Patton Murray hot spot ridge that extends 200 km toward the east across the north Pacific. Estimates of tsunami repeat times from paleotsunami studies indicate that the Semidi segment could be near the end of its current inter-seismic cycle. GPS records from Chirikof Island at the shelf edge indicate 90% locking of plate interface faults. An earthquake in the shallow Semidi subduction zone could generate a tsunami that will inundate the US west coast more than the 1946 and 1964 earthquakes because the Semidi continental slope azimuth directs a tsunami southeastward.