The oxidation of drugs by fishes
Comparative Biochemistry and Physiology, Part A: Molecular & Integrative Physiology
By: Donald R. Buhler and Mary E. Rasmusson
Links
- More information: Publisher Index Page (via DOI)
- Download citation as: RIS | Dublin Core
Abstract
1. Fish liver microsomal systems have been found to catalyze the hydroxylation of aniline and acetanilide, the N-demethylation of aminopyrine and the O-dealkylation of phenacetin.
2. These systems are similar to the corresponding mammalian enzymes and they may be considered to be mixed function oxidase since they require NADPH and oxygen. An absolute requirement for oxygen, however, was difficult to demonstrate for the hepatic phenacetin cleavage system from fish.
3. Microsomal drug metabolizing systems from fish have temperature optima which are considerably lower than those of corresponding mammalian systems
| Publication type | Article |
|---|---|
| Publication Subtype | Journal Article |
| Title | The oxidation of drugs by fishes |
| Series title | Comparative Biochemistry and Physiology, Part A: Molecular & Integrative Physiology |
| DOI | 10.1016/0010-406X(68)90931-6 |
| Volume | 25 |
| Issue | 1 |
| Year Published | 1968 |
| Language | English |
| Publisher | Elsevier |
| Contributing office(s) | Columbia Environmental Research Center |
| Description | 17 p. |
| First page | 223 |
| Last page | 239 |
| Online Only (Y/N) | N |
| Additional Online Files (Y/N) | N |
| Google Analytic Metrics | Metrics page |