Degradation of organophosphates by fish liver phosphatases
Journal of the Fisheries Research Board of Canada
By: James W. Hogan and Charles O. Knowles
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Abstract
Liver homogenates of bluegill, Lepomis macrochirus Rafinesque, and channel catfish, Ictalurus punctatus (Walbaum), were shown by a manometric technique to contain soluble enzymes capable of degrading diisopropyl phosphorofluoridate (DFP) and 2,2-dichlorovinyl dimethyl phosphate (dichlorvos). Hydrolysis of the compounds was greatest in the presence of the manganic ion. Tentative identification of certain of the hydrolysis products suggested that cleavage of the anhydride bond was a degradation pathway for DFP and dichlorvos in vitro under the assay conditions employed. Substrate summation, inhibition, and activation experiments failed to clearly indicate more than a single enzyme hydrolyzing DFP and dichlorvos in the two fish.
| Publication type | Article |
|---|---|
| Publication Subtype | Journal Article |
| Title | Degradation of organophosphates by fish liver phosphatases |
| Series title | Journal of the Fisheries Research Board of Canada |
| DOI | 10.1139/f68-142 |
| Volume | 25 |
| Issue | 8 |
| Year Published | 1968 |
| Language | English |
| Publisher | NRC Research Press |
| Contributing office(s) | Columbia Environmental Research Center |
| Description | 9 p. |
| First page | 1571 |
| Last page | 1579 |
| Online Only (Y/N) | N |
| Additional Online Files (Y/N) | N |
| Google Analytic Metrics | Metrics page |