Chronic oral DDT toxicity in juvenile coho and chinook salmon

Toxicology and Applied Pharmacology
By: , and 



Technical and p,p′-DDT was incorporated into test diets and fed to juvenile chinook and coho salmon for periods as long as 95 days. Pure p,p′-DDT was slightly more toxic to young salmon than was the technical DDT mixture. Chinook salmon appeared to be 2–3 times more sensitive to a given concentration of DDT in the diet than were coho salmon. The size of the fish greatly influenced toxicity, smaller younger fish being more susceptible to a given diet than larger older fish. The dose of DDT accumulated within the median survival time ranged from 27–73 mg/kg for chinook salmon and from 56–72 mg/kg for coho salmon. The extrapolated 90-dose LD50 (Hayes, 1967) for young chinook and coho salmon were 0.0275 and 0.064 mg/kg/day, respectively. Liver size decreased on prolonged feeding with DDT, and carcass lipid content was increased. A severe surface ulceration of the nose region appeared in coho salmon fed DDT over long periods. In addition, an interesting localized degeneration of the distal convoluted tubule was observed in the kidney of coho salmon receiving DDT.

Publication type Article
Publication Subtype Journal Article
Title Chronic oral DDT toxicity in juvenile coho and chinook salmon
Series title Toxicology and Applied Pharmacology
DOI 10.1016/0041-008X(69)90014-3
Volume 14
Issue 3
Year Published 1969
Language English
Publisher Elsevier
Contributing office(s) Columbia Environmental Research Center
Description 21 p.
First page 535
Last page 555
Online Only (Y/N) N
Additional Online Files (Y/N) N
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