Rock uplift rates can be difficult to measure over 10³–10⁵ yr time scales. If, however, a landscape approaches steady state, where hillslope erosion and rock uplift rates are steady and locally similar, then it should be possible to quantify rock uplift rates from hillslope erosion rates. Here, we test this prediction by comparing channel steepness index values and ¹⁰Be catchment-averaged erosion rates to well-constrained rock uplift rates in two landscapes in Italy. The first field area is the Romagna Apennines, northern Italy, where rock uplift rates are relatively uniform, between 0.2 and 0.5 mm/yr (regional mean 0.40 ± 0.15 [SE] mm/yr), and have been steady since 0.9 Ma. The second area is the region around northeastern Sicily and the southernmost Italian peninsula, where rock uplift rates are higher and exhibit a strong spatial gradient, from ∼0.7 to ∼1.6 mm/yr (regional mean 1.09 ± 0.13 [SE] mm/yr). In both regions, channel steepness indices and ¹⁰Be erosion rates vary directly with rock uplift rates. Although there is considerable variability in erosion rates, regionally averaged rates in both the northern (0.46 ± 0.04 [SE] mm/yr) and southern (1.21 ± 0.24 [SE] mm/yr) areas accurately measure rock uplift rates. Although channel steepness indices do not quantify rock uplift rates, they are useful for (1) identifying regional patterns of rock uplift, (2) identifying areas where uplift rates might be expected to be uniform, and (3) informing ¹⁰Be sampling strategies. This study demonstrates that, together, channel steepness and hillslope erosion rates can provide a powerful tool for determining rock uplift rates.