In evaluating potential impacts of climate change on water resources, water managers seek to understand how future conditions may differ from the recent past. Studies of climate impacts on groundwater recharge often compare simulated recharge from future and historical time periods on an average monthly or overall average annual basis, or compare average recharge from future decades to that from a single recent decade. Baseline historical recharge estimates, which are compared with future conditions, are often from simulations using observed historical climate data. Comparison of average monthly results, average annual results, or even averaging over selected historical decades, may mask the true variability in historical results and lead to misinterpretation of future conditions. Comparison of future recharge results simulated using general circulation model (GCM) climate data to recharge results simulated using actual historical climate data may also result in an incomplete understanding of the likelihood of future changes. In this study, groundwater recharge is estimated in the upper Colorado River basin, USA, using a distributed-parameter soil-water balance groundwater recharge model for the period 1951–2010. Recharge simulations are performed using precipitation, maximum temperature, and minimum temperature data from observed climate data and from 97 CMIP5 (Coupled Model Intercomparison Project, phase 5) projections. Results indicate that average monthly and average annual simulated recharge are similar using observed and GCM climate data. However, 10-year moving-average recharge results show substantial differences between observed and simulated climate data, particularly during period 1970–2000, with much greater variability seen for results using observed climate data.