The Pliocene epoch represents an important transition from a climate regime with high-frequency, low-amplitude oscillations when the Northern Hemisphere lacked substantial ice sheets, to the typical high-frequency, high-amplitude Middle to Late Pleistocene regime characterized by glacial—interglacial cycles that involve waxing and waning of major Northern Hemisphere ice sheets. Analysis of middle Pliocene (∼3 Ma) marine and terrestrial records throughout the Northern Hemisphere forms the basis of an integrated synoptic Pliocene paleoclimate reconstruction of the last significantly warmer than present interval in Earth history. This reconstruction, developed primarily from paleontological data, includes middle Pliocene sea level, vegetation, land—ice distribution, sea—ice distribution, and sea-surface temperature (SST), all of which contribute to our conceptual understanding of this climate system. These data indicate middle Pliocene sea level was at least 25 m higher than present, presumably due in large part to a reduction in the size of the East Antarctic Ice Sheet. Sea surface temperatures were essentially equivalent to modern temperatures in tropical regions but were significantly warmer at higher latitudes. Due to increased heat flux to high latitudes, both the Arctic and Antarctic appear to have been seasonally ice free during the middle Pliocene with greatly reduced sea ice extent relative to today during winter. Vegetation changes, while more complex, are generally consistent with marine SST changes and show increased warmth and moisture at higher latitudes during the middle Pliocene.