Next-generation lampricides: A three-stage process to develop improved control tools for invasive sea lamprey
Canadian Journal of Fisheries and Aquatic Sciences
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Abstract
Successful integrated management of the invasive predatory sea lamprey (Petromyzon marinus) in the Laurentian Great Lakes of North America is owed largely to the long history of beneficial use of two lampricides: 3-trifluoromethyl-4-nitrophenol (TFM) and 2′,5-dichloro-4′-nitrosalicylanilide (niclosamide). Ensuring continued successful sea lamprey control necessitates consideration of possible next-generation lampricides to supplement or replace current lampricides. This review identifies fifteen hallmarks of success for current lampricides to be used as design criteria in a search for next-generation lampricides. A three-stage research approach is outlined. Targeted research using omics, computer modelling, and high-throughput technology to define molecular mechanisms and high probability molecular targets for sea lamprey selective toxic action is crucial to prioritizing chemical candidates. Targeted delivery or identifying synergists to existing or new lampricides can provide increased efficiency and reduced environmental impact. Ultimate development of next-generation lampricides will rely on traditional toxicity testing methodologies to ensure safety and regulatory compliance.
Suggested Citation
Lantz, S., Adair, B., Amberg, J., Bergstedt, R.A., Boogaard, M.A., Bussy, U., Docker, M.F., Dunlop, E.S., Gonzalez, A., Hubert, T., Siefkes, M.J., Sullivan, P., Whyard, S., Wilkie, M.P., Young, B., Muir, A.M., 2022, Next-generation lampricides: A three-stage process to develop improved control tools for invasive sea lamprey: Canadian Journal of Fisheries and Aquatic Sciences, v. 79, no. 4, p. 692-702, https://doi.org/10.1139/cjfas-2020-0316.
| Publication type | Article |
|---|---|
| Publication Subtype | Journal Article |
| Title | Next-generation lampricides: A three-stage process to develop improved control tools for invasive sea lamprey |
| Series title | Canadian Journal of Fisheries and Aquatic Sciences |
| DOI | 10.1139/cjfas-2020-0316 |
| Volume | 79 |
| Issue | 4 |
| Year Published | 2022 |
| Language | English |
| Publisher | Canadian Science Publishing |
| Contributing office(s) | Upper Midwest Environmental Sciences Center |
| Description | 11 p. |
| First page | 692 |
| Last page | 702 |