Faults and folds on the southern flank of the Ozark dome in northern Arkansas, USA, record flexural extension in a foreland area followed by shortening in response to the late Paleozoic Ouachita orogeny. Map-scale structures and an analysis of fault-slip data collected systematically during geologic mapping demonstrate that most deformation in the area accommodated north-south extension as the southern margin of Laurentia was flexed beneath the thrust load of the Ouachita belt, probably during Middle Pennsylvanian. Extension was concentrated in northeast- and west-northwest-trending structural zones having sets of discontinuous, often en echelon normal and strike-slip faults and associated monoclinal folds. Reactivation of basement weaknesses that underlie these zones is indicated by their close match to oblique-rift models in which both the proportions of normal and strike-slip faulting and the internal extension directions vary with orientation of the zones. Subsequent propagation of north-south Ouachita shortening into the foreland formed small-offset strike-slip and sparse reverse faults that overprinted older extensional structures. Strike-slip faults were concentrated in reactivated northeast-trending structural zones. In two areas, reverse faults and local anticlines were developed in the footwalls of older normal faults, both near intersections of northeast- and west-northwest-trending structural zones. These are interpreted as areas of incipient inversion due to compressional stress concentrations at fault-block corners. Spatial overlap of areas of north-south shortening and fluid flux marked by silicification or lead-zinc mineralization indicates that regional fluid flow of brines was coeval with and may have enhanced inversion during Late Pennsylvanian to early Permian.