Application of updated diatom biochronology to the Monterey Formation and related biosiliceous rocks reveals the imprint of both global paleoclimatic/ paleoceanographic and regional tectonic events. A rise in global sea level combined with regional tectonic deepening associated with the development of the transform California margin resulted in the abrupt onset of deposition of fine-grained Monterey sediments between 18 and 16 Ma. The base of the Monterey does not mark a silica shift in diatom deposition from the North Atlantic to the North Pacific. Rather, a North Atlantic decline of diatoms after ~13 Ma and increasing divergence in nutrient levels between the North Atlantic and North Pacific between ~13 and 11 Ma, coincided with a major enhancement of diatom deposition in the Monterey Formation. A stratigraphically condensed interval of phosphate-rich sediments between 13 and 10 Ma in coastal southern California appears to have resulted from sediment starvation on offshore banks during a period of higher sea level, as inland sections commonly contain thick sequences of diatomaceous sediment. Increasing latitudinal thermal gradients in the latest Miocene, which triggered a biogenic bloom in the equatorial Pacific at 8 Ma, also lead to enhanced diatom deposition in the uppermost Monterey and overlying biosiliceous rocks. Uplift of the California coastal ranges after ~5.2 Ma resulted in an increasing detrital contribution that obscured the presence of diatoms in onshore sediments. Major reduction in coastal upwelling in the early Pliocene at ~4.6 Ma caused a drastic reduction of diatoms in sediments of offshore southern California.