Site response, sedimentary basin amplification, and earthquake stress drops for the Portland, Oregon area were determined using accelerometer recordings at 16 sites of 10 local earthquakes with MDMD 2.6–4.0. A nonlinear inversion was applied to calculate site response (0.5–10 Hz), corner frequencies, and seismic moments from the Fourier spectra of the earthquakes. Site amplifications at lower frequencies of 0.1–2.0 Hz were determined from Fourier spectra of four regional earthquakes with MwMw 5.8–6.4. Amplifications were calculated relative to a stiff‐soil site outside the Portland and Tualatin basins. Sites on artificial fill and Holocene alluvium show strong amplification peaks (factor of 5) around 1–2 Hz. Sites on the Portland Hills, consisting of thin soil over basalt, display spectral peaks at 4–5 Hz (factor of 4). Spectral peaks at both sites are similar to those predicted for vertically propagating S waves from VSVS profiles determined at these sites using a borehole and refraction microtremor analysis. The largest amplifications at 0.1–1 Hz were found at stiff‐soil sites in the Tualatin basin, based on recordings of regional earthquakes. Amplifications of a factor of 10, at about 0.3 Hz, were observed for a site in the deeper portion of the Tualatin basin and a factor of 7 at 0.5–0.6 Hz for two adjacent sites closer to the border of that basin. Stiff‐soil sites in the Portland basin exhibit amplifications of 2–3 at frequencies of about 0.3–0.8 Hz. The frequencies of the amplification peaks for the deep Tualatin basin site can be explained by S‐wave resonance in the shallow sediments, but the observed amplification is underestimated. Earthquake stress drops determined from the inversion range from 3 to 11 MPa, with no overall dependence on seismic moment.