The deep structure of the Newfoundland Appalachian orogen is investigated by analyses of three intersecting seismic refraction/wide-angle reflection profiles which traverse the Gander and Dunnage zones or central mobile belt of Newfoundland. A simultaneous travel time inversion for velocity and interface was applied to the in-line seismic refraction/wide-angle reflection data and constrained by synthetic amplitude models. The results of the modeling procedure show a subhorizontally layered crust with upper crustal velocities ranging from 5.4 to 6.2 km/s, a midcrustal velocity of 6.25–6.35 km/s, and a lower crustal velocity of 6.7±0.2 km/s. The top of the lower crust is marked by a series of prominent reflections between 18 and 23 km depth which suggest a complex layered velocity interface. Strong laterally coherent Moho reflections indicate a sharp crust-mantle transition at 35 ± 3 km. The uppermost mantle has a velocity of 8.0±0.2 km/s, and a reflecting horizon at 55 km depth suggests an increase to velocities approaching 8.5 km/s. Normal moveout corrections applied to fan profiles provide constraining evidence for the reflecting horizon at the top of the lower crust and laterally continuous Moho reflections at 11–12 s two-way travel time. Comparisons with a coincident deep seismic reflection profile show that the refraction and reflection Mohos match to better than 2–3 km. Bulk Poisson's ratios of 0.23–0.24 for the whole crust calculated from P_mP/S_mS travel times suggest a crust dominated by quartzofeldspathic lithologies and a notable absence of voluminous mafic additions to the lower crust. The absence of a deep crustal root, coupled with the bulk intermediate composition inferred for the lower crust from the seismic refraction/wide-angle data, implies that the crust beneath central Newfoundland has undergone multiple periods of reactivation and equilibration following successive orogenic episodes.