Indiana’s water resources—in streams and lakes, in plants and soils, and underground—are a critical component of the state’s economy and well-being. Availability of this important resource is driven by precipitation and temperature patterns, both of which have shifted in recent decades, and is also highly influenced by how we manage natural and human systems. As local temperatures continue to rise and rainfall patterns shift, managing the multiple water needs of communities, natural systems, recreation, industry, and agriculture will become increasingly difficult. Ensuring that enough water is available in the right places and at the right times will require awareness of Indiana’s changing water resources and planning at regional and state levels. This report from the Indiana Climate Change Impacts Assessment (IN CCIA) applies climate change projections for the state to explore how continued changes in Indiana’s climate are going to affect all aspects of water resources, including soil water, evaporation, runoff, snow cover, streamflow, drought, and flooding. The findings presented here are primarily based on the IN CCIA Water Resources Working Group technical report (Cherkauer et al., 2021) and the IN CCIA report Indiana’s Past and Future Climate (Widhalm et al., 2018).