The Pogo Au deposit is the largest of a number of gold occurrences in eastern interior Alaska, that occur along a broad trend from west of Pogo to Black Mountain. Some of these occurrences are hosted in amphibolite facies gneisses and others in mid-Cretaceous igneous rocks that intruded the older metamorphic rocks. All occurrences contain arsenopyrite and pyrite. Whole rock geochemical trends distinguish most metamorphic rock-hosted vein prospects (strong Bi-Te-Au correlations) and intrusion-hosted occurrences (weak As-Au correlations). Brecciated quartz veins in metamorphic rocks have paragentically late Bi-Te (±S) + Au that post-dates Fe-As sulphide deposition. High grade vein samples from the Tibbs Creek intrusion-hosted deposits contain pyrite and arsenopyrite, generally lack Bi-Te minerals, but can contain paragentically younger euhedral quartz, stibnite and carbonate. Cathodoluminescence studies of gold-rich samples indicate that quartz dissolution occurred during the syn- to post-tectonic Bi-Te-Au deposition, and the later stibnite event. In the case of metamorphic rock-hosted deposits (e.g., Pogo, Gray Lead), Bi-Te and gold deposition commonly occurs in microfractures within quartz veins; the limited quartz in these fractures have distinctive CL response. We propose that gold deposition is related to changes in P-T conditions rather than fluid-rock chemical reactions. Similar quartz dissolution textures affect the void-filling euhedral quartz before or during stibnite and carbonate mineralization in the high-grade Au samples from Blue Lead.