The layer-structure minerals serpentine, brucite, and talc are postulated to form in the mantle wedge above a subducting slab as a result of progressive hydration and silica metasomatism. Tectonic mixing at the slab-mantle interface generates serpentinite mélanges that contain blocks of high-pressure (HP) or ultrahigh-pressure (UHP) metamorphic rock derived from the subducting slab. Such serpentinite mélanges may provide a means of exhumation of HP/UHP metamorphic rocks, and may define the lower limit of locked regions on the subduction interface that fail in large earthquakes. We review recently obtained frictional strength data for brucite and talc over the temperature range 25-400°C at 100 MPa effective normal stress and compare them with new data for antigorite. These minerals respond to heating in different ways, causing their frictional strengths to diverge. Water-saturated antigorite strength increases toward the fixed dry value of μ ≈ 0.75-0.80 with heating: μ ≈ 0.50 at 25°C and μ > 0.60 at 400°C. The difference in μ between dry and watersaturated talc gouge also decreases with increasing temperature, but both the dry and watersaturated values of μ are lower at elevated temperatures. For dry talc, μ decreases from 0.35 to 0.25 between 25° and 300°C, whereas for water-saturated talc, μ is approximately 0.20 at 25°C and 0.10-0.15 at elevated temperatures. Weakening of the interlayer bond of talc with heating may be responsible for the overall reduction in its frictional strength. The strength of dry brucite also is fixed at μ = 0.45-0.50, but the water-saturated value of μ decreases from ≈0.30 at 25°C to 0.20-0.25 at 200°-400°C. The water-saturated brucite gouge has extensively recrystallized along the shear surfaces, and its weakening may be attributable to solution-transfer processes.