The Cross-Hosgri slope is a bathymetric lineament that crosses the main strand of the Hosgri fault offshore Point Estero, central California. Recently collected chirp seismic reflection profiles and sediment cores provide the basis for a reassessment of Cross-Hosgri slope origin and the lateral slip rate of the Hosgri fault based on offset of the lower slope break of the Cross-Hosgri slope. The Cross-Hosgri slope is comprised of two distinct stratigraphic units. The lower unit (unit 1) overlies the post–Last Glacial Maximum transgressive erosion surface and is interpreted as a Younger Dryas (ca. 12.85–11.65 ka) shoreface deposit based on radiocarbon and optically stimulated luminescence (OSL) ages, Bayesian age modeling, seismic facies, sediment texture, sediment infauna, and heavy mineral component. The shoreface was abandoned and partly eroded during rapid sea-level rise from ca. 11.5 to 7 ka. Unit 2 consists of fine sand and silt deposited in a midshelf environment when the rate of sea-level rise slowed between ca. 7 ka and the present. Although unit 2 provides a thin, relatively uniform cover over the lower slope break of the older shoreface, this feature still represents a valuable piercing point, providing a Hosgri fault slip rate of 2.6 ± 0.8 mm/yr. Full-waveform processing of chirp data resulted in significantly higher resolution in coarser-grained strata, which are typically difficult to interpret with more traditional envelope processing. Our novel combination of offshore radiocarbon and OSL dating is the first application to offshore paleoseismic studies, and our results indicate the utility of this approach for future marine neotectonic investigations.