The first multidisciplinary characterisation of Bowditch Seamount in the Sargasso Sea was conducted to provide new baseline knowledge of the biodiversity, geomorphology, oceanography and glacial history of this seamount. A dropframe camera transect 1483–1562 m deep on the seamount documented 77 megafaunal taxa including Vulnerable Marine Ecosystem indicator taxa such as sponges, cold-water corals, and stalked crinoids. Seabed terrain analysis of multibeam echosounder data showed species varied significantly along this transect in response to local geomorphological variability (R²_adj = 31%, p < 0.0001), with changes in seafloor relief and substrata driving species composition over the seamount. ¹⁴C-calibrated and ²³⁰Th-ages of fossil corals (Desmophyllum dianthus) collected by Van Veen grabs 1517 m deep showed corals thrived on the seamount ∼24 ka BP and ∼17 ka BP. Abrupt excursions between higher and lower radiogenic ε_Nd-composition values of the skeletons suggested that D. dianthus persisted on the seamount over times of southern source water input and detrital sediments from the melting Laurentide Ice Sheet, respectively. In agreement with other studies from the western North Atlantic, living D. dianthus were absent in the contemporary setting at these depths, and suggest a significant re-organisation of the seamount community since the deglacial when ice-rafted debris of carbonates likely resulted in a lower aragonite compensation depth allowing D. dianthus to proliferate at deeper depths. New conductivity-depth-temperature profiling revealed the seamount at these depths is now bathed by highly oxygenated Labrador Sea Water (LSW) formed at high latitudes. Co-analysis of a newly constructed 70-year long time series of temperature and salinity for the Labrador Sea and Bermuda regions revealed a 10-year transit time from high latitudes to Bowditch Seamount. This multidisciplinary approach shows how geomorphology drives local biodiversity patterns, but also how upstream climatic forcing in subpolar regions may influence Bermuda's subtropical seamount ecosystem.