Across coastal areas of the northern Gulf of Mexico, the Deepwater Horizon oil spill resulted in significant ecological injury, and over 8 billion USD directed to restoration activities. Oyster restoration projects were implemented with regional goals of restoring oyster abundance, spawning stock, and population resilience. Measuring regional or large-scale ecosystem restoration outcomes challenges traditional project-specific monitoring and outcome reporting. We examine the outcomes of oyster restoration at the project-level and discuss potential pathways to measure progress toward region-level goals. An estimated 15 km² of oyster habitat was restored across 11 different estuaries with 62 individual reef footprints created, ranging in size from ~0.2 to 1.45 km². Individual sites were distributed across the salinity gradient, and all reefs were subtidal. One-year post-restoration, mean total oyster density across all sites was 53.0 ± 60.7 ind m⁻² of which 38.4 ± 42.2 ind m⁻² were adult (>25 mm shell height) oysters. Recent data (2018/2019) available for all sites indicates reduced densities of total oysters (44.6 ± 70.9 ind m⁻²) and adult oysters (14.6 ± 21.6 ind m⁻²). These data provide insight into project specific outcomes, suggesting an overall enhancement in oyster abundance compared to pre-restoration, but fall short of informing outcomes at the regional-level that incorporate cumulative effects on adjacent and connected reef populations, or inform overall resiliency of the regional oyster resource. Developing regional outcome benchmarks that enable assessment of cumulative and synergistic impacts of individual projects may benefit from broader spatial and temporal monitoring requirements that can better inform development of regional tools or models. Such tools would enable cumulative effects analyses examining net resource change, resilience and assess impacts of restoration activities on regional resource status.