Dust events originate from multiple sources in arid and semi-arid regions, making it difficult to quantify source contributions. Dust geochemical/mineralogical composition, if the sources are sufficiently distinct, can be used to quantify the contributions from different sources. To test the viability of using geochemical and mineralogical measurements to separate dust-emitting sites, we used dust samples collected between 2018 and 2020 from ten National Wind Erosion Research Network (NWERN) sites that are representative of western United States (US) dust sources. Dust composition varied seasonally at many of the sites, but within-site variability was smaller than across-site variability, indicating that the geochemical signatures are robust over time. It was not possible to separate all the sites using commonly applied principal component analysis (PCA) and cluster analysis because of overlap in dust geochemistry. However, a linear discriminant analysis (LDA) successfully separated all sites based on their geochemistry, suggesting that LDA may prove useful for separating dust sources that cannot be separated using PCA or other methods. Further, an LDA based on mineralogical data separated most sites using only a limited number of mineral phases that were readily explained by the local geologic setting. Taken together, the geochemical and mineralogical measurements generated distinct signatures of dust emissions across NWERN sites. If expanded to include a broader range of sites across the western US, a library of geochemical and mineralogical data may serve as a basis to track and quantify dust contributions from these sources.