Recent geologic and geophysical investigations were undertaken in northeastern Oregon to better assess earthquake hazards in the region and determine relative favorability for geothermal energy development on lands of the Confederated Tribes of the Umatilla Indian Reservation (CTUIR). This work was funded in part by a Bureau of Indian Affairs grant awarded to the CTUIR to identify areas most suitable for further exploration of geothermal resources. Results from this work were utilized as inputs to a geothermal favorability modeling process that led to the identification of target sites for further geothermal investigation. Beyond the geothermal aspect of this project, the region is of great tectonic significance as it marks the intersection of two major physiographic and geophysical features, the Klamath-Blue Mountain lineament (KBL) and Olympic-Wallowa lineament (OWL), inferred to represent major basement boundaries. The Thorn Hollow and Hite faults, which appear to be major linkages between the KBL and OWL, run through the study area. New aeromagnetic, gravity and magnetotelluric (MT) surveying, along with fault analyses, were conducted as part of this effort. Detailed geophysical exploration resulted in the collection of 1,380 new gravity stations, 34,524-line kilometers of aeromagnetic data (covering 12,524 km2) and measurements from 36 MT stations. Two-dimensional (2D) forward-modeling was executed along several profiles using gravity and aeromagnetic data, combined with existing geologic mapping and rock property constraints measured from hand samples and outcrops. These models are used to define lithologic contacts in the subsurface in the absence of well logs or borehole data to determine possible geothermal fluid reservoirs, as well as identify major structures that may act as conduits for the upward migration of geothermal fluids.