Goals of conservation research include detecting and monitoring changes in abundance, understanding species interactions, detecting extinction events of imperiled species, and detecting colonization events and spread of non-native species. Achieving these goals is difficult or impossible when the target species is rarely encountered or when the number of individuals detected is unrelated to the true population size, as is often the case with snakes. Here, we review the challenges that low species-level and individual-level detection probability cause for snake conservation research, present four case studies demonstrating approaches we have used to overcome low detection probability, and highlight priority areas for future research and method development.