Accommodation space governs the spatial and temporal distributions of sediments in continental margins. Mapping the sedimentation patterns, therefore, offers insights into the solid-Earth processes that shape accommodation space. We assembled an unprecedented amount of seismic and borehole data along the Eastern North American Margin and used it to divide the margin's sedimentary package into eight chronostratigraphic intervals, identifying temporal shifts in depocenters under the continental shelf, slope, and rise. The Jurassic depocenters follow the syn-rift structure and its thermal subsidence loci. The Long Island Platform is the only margin segment where the early post-rift sediment thickness matches subsidence predictions from uniform-stretching models, whereas in Georges Bank Basin (GBB) and Baltimore Canyon Trough (BCT), sediment thickness is 1.5–3 times higher than predicted, pointing to other factors at play. A margin-wide Jurassic transient shoulder uplift is inferred from the occurrence of stratigraphic onlaps above thinned crust. Unlike the Jurassic, the Cretaceous and Cenozoic depocenters disregard the inherited subsidence pattern. The accommodation space over the shelf and coastal plain during the Cretaceous was affected by regional isostatic compensation of the sedimentary loads accumulated on the shelf and rise. Accommodation space development in the GBB was interrupted during the Cretaceous after the margin crossed the Great Meteor Hotspot track, resulting in a widespread permanent uplift, erosion, and sediment redistribution. The distribution of anomalous Neogene subsidence in the BCT challenges previous suggestions of mantle dynamic control on the accommodation space and favors flexural downwarping of the shelf by sediment accumulation on the rise.