Cretaceous through Eocene plutonic rocks in northeastern Washington, USA, document a 60 m.y. history of crustal thickening and subsequent collapse and extension in response to two terrane-accretion events. Rocks emplaced 113–53 Ma have increasing La/Yb ratios reflecting orogenic plateau development after arrival of the Insular terrane by 100 Ma. Plutons emplaced 52–45 Ma (the Challis episode) document collapse of this plateau and define a SW-younging age progression attributed to breakoff and rollback of the Farallon slab following accretion of the Siletzia terrane at ca. 50 Ma. All of the rocks have chemical traits of arc magmas, likely inherited from their lower-crustal sources, but low B/Be ratios and the lack of evidence for amphibole fractionation indicate the Eocene magmas formed under drier conditions than are typical of active subduction settings. These magmas also originated at greater depth (eclogitic vs. gabbroic source) and were emplaced more shallowly than the earlier ones. All rocks have overlapping Sr-Nd and O isotopic data, indicating significant contributions from older continental crust, and depleted mantle Nd model ages become older toward the east, defining three regions that correspond with previously inferred lower-crustal domains. Farallon slab rollback also drove extension (core complex formation, dike swarms) and crustal uplift, which, along with voluminous magmatism, define the Challis episode. This tectonic model is further supported by seismic tomography, which has identified remnants of a detached slab in the upper mantle beneath the region.