A large source of error in SO₂ emission rates derived from mobile Differential Optical Absorption Spectroscopy (DOAS) of volcanic gas plumes is the uncertainty in atmospheric light paths between the sun and the instrument, particularly under non-ideal atmospheric conditions, such as the presence of low clouds. DOAS instruments measure the SO₂ column density along the effective light path, so changes to that pathway directly affect the measured SO₂ signal. Due to complex radiative transfer mechanisms when a cloud is between the DOAS viewing position and a volcanic plume, measured plumes can appear spatially offset from their true location, a phenomenon informally referred to as “ghost plumes.” In addition to the appearance of ghost plumes, DOAS measurements recorded in non-ideal conditions have poorly characterized errors and are often discarded, limiting the data available to characterize volcanic degassing. In this study we simulate the radiative transfer associated with zenith-facing mobile DOAS traverses using the McArtim radiative transfer model for scenarios when there is a cloud layer between the instrument and the volcanic plume. In total, 217 permutations of atmospheric optical conditions are considered with varying cloud opacities (AOD = 0, 1, 2, 4, 8, 20), plume opacities (AOD = 0, 1, 2, 4, 8), solar zenith angles (SZA = 1°, 30°, 60°), and cloud thicknesses (200, 400, 800 m). We first develop objective criteria for selecting SO₂ baseline absorption levels and plume spatial extents. The simulated plume traverses are then integrated to obtain the SO₂ cross-sectional burdens which, after multiplication with the wind speed, yield SO₂ emission rates. We find large modification in the shape of the modeled cross-sectional burdens even under translucent (low AOD) cloud conditions in our modeled scenarios. Despite modification of the plume shape, the presence of a low cloud layer is typically not a large source of error in the SO₂ cross-sectional burden or emission rate obtained from zenith-facing DOAS traverses. We find that all measured cross-sectional burdens simulated using an aerosol-free plume in the above conditions and SZA ≤ 30° are within ±25% of the true value.