Models for crustal growth commonly involve the accretion of dominantly juvenile crust to continental margins. However, tracking the provenance and tectonic affinity of dominantly juvenile crustal provinces is challenging. This difficulty is highlighted by uncertainty over whether the Yavapai and Mojave Provinces, part of the >1300-km-wide system of Proterozoic orogens in southwestern Laurentia, (1) have similar crustal and tectonic histories and (2) if they formed on or near Laurentian, Australian, or Antarctic cratons. Here, we contribute new large-n detrital zircon U-Pb geochronology and Sm-Nd whole-rock isotope geochemistry to help constrain the provenance of the Yavapai Province and address these broader questions. Yavapai Province metasedimentary rocks from central Colorado in the southwestern USA have abundant pre-1.80 Ga detrital zircon grains, with ca. 1.85 Ga, 2.30 Ga, and 2.50−2.70 Ga peaks, and variable amounts of 1.79−1.78 Ga grains. Evolved whole-rock Sm-Nd isotopic compositions from these rocks, including 2.36−2.08 Ga model ages, also suggest mixing between 1.79 Ga and 1.78 Ga Yavapai Province arcs and early Proterozoic to Archean sources. Nearly identical pre-1.8 Ga detrital and inherited zircon age distributions suggest that the Yavapai and Mojave Provinces formed on and/or incorporated similar material. The Trans-Hudson orogen, and to a slightly lesser extent the Penokean orogen, provide the closest matches to the pre-1.80 Ga material in the Yavapai and Mojave Provinces. This similarity, coupled with a weaker resemblance to Australian and Antarctic sources, support a Laurentian affinity for the Yavapai and Mojave Provinces. We envision Paleoproterozoic arc formation on both oceanic crust and material of Laurentian affinity and multiple phases of arc-back-arc genesis, closure, and accretionary tectonism along the long-lived margin of the supercontinent Columbia (Nuna).