Translocating amphibians to alternative, suitable habitat is a climate adaptation strategy aimed at minimizing the risk of extinction due to projected global warming and drying. Projected conditions could undermine their physiological performance, and thus survival and reproduction. Translocations minimize risks of extinction by increasing spatial redundancy across climate-resilient habitats, particularly for dispersal-limited species. However, outcomes of amphibian translocation attempts are poorly documented, and their effectiveness remains unclear. We released and tracked 34 Eleutherodactylus coqui to determine early postrelease survival of a control (nontranslocated) group (n = 14) and experimental (translocated) group (n = 20) moved 0.8 km from their capture location in west-central Puerto Rico in 2021. We defined “initial” as the first 17 d postrelease, a period during which we hypothesized that experimental individuals would have lower survival rates because they transitioned from known-familiar to novel-unfamiliar habitat. We found no evidence in the data to support our hypothesis. Daily survival rates were better explained by a model with no group effect but negatively influenced by in situ temperature. However, the effect of in situ temperature (proxy of operative temperature) was weak (95% confidence intervals overlapped 0). After 17 d, all but one of the recaptured frogs lost weight for a combined weight loss of 0.28 ± 0.13 g. However, weight loss was significantly higher in translocated frogs (0.81 ± 0.33 g). Average daily movements did not hinder survival even though experimental individuals traveled farther (～ eight times) than control ones. Our findings suggested that managed translocations have the potential to become a useful conservation tool, not an additive source of mortality. We outline challenges that remain before translocations of Eleutherodactylus species can be broadly applied.