The increased demand for clean energy technology and a significant reliance on foreign supply chains have given impetus to understanding critical mineral systems and locating potential resources within the United States. At least thirteen critical mineral-bearing systems have been identified throughout the U.S. southern Midcontinent (Hofstra and Kreiner, 2020) but much of the region’s geologic framework is concealed by vegetation and sedimentary cover that hinder traditional geologic mapping efforts. Airborne geophysical data provide an effective way to overcome these obstacles and to provide additional insight into the deeper structures that underlie shallow mineralization. However, legacy airborne magnetic and radiometric data were collected using now-outdated instruments and methods, inconsistent survey parameters, and large flight-line spacings resulting in low-resolution data that present challenges to regional-scale study and interpretation. Over the last decade, the U.S. Geological Survey Earth Mapping Resources Initiative (EMRI) and National Cooperative Geologic Mapping Program have conducted a series of high-resolution airborne magnetic and radiometric surveys across the southern Midcontinent (Fig. 1) as part of an effort to improve understanding of the geophysical framework and natural resource potential in the region. These surveys are designed using modern survey methods and instruments with consistent parameters for flight-line spacing and flight height relative to magnetic sources. The EMRI airborne surveys are planned in collaboration with State geological surveys based on focus areas (Dicken et al., 2022) according to the presence of or potential for critical mineral deposits. High-resolution airborne magnetic and radiometric data cover focus areas such as the southeast Missouri iron metallogenic province and South-Central iron-oxide-apatite (IOA) – iron-oxide-copper-gold (IOCG) province, the Magnet Cove alkaline-carbonatite complex, the Midwest Permian ultramafic dike district, the Illinois-Kentucky fluorspar district, and several Mississippi Valley-type lead-zinc deposits and districts (Fig. 1). These focus areas represent known deposits or prospective host systems of critical minerals including rare earth elements (REEs), platinum-group elements (PGEs), cobalt, lithium, fluorspar, niobium, titanium, vanadium, lead, zinc, gallium, germanium, and many more. Other significant geologic and geophysical features covered include the Reelfoot rift, the New Madrid seismic zone, the Illinois basin, the Arkoma basin, the South-Central magnetic lineament, and the Kentucky-Tennessee magnetic anomaly (Fig. 1). This presentation focuses on new airborne magnetic and radiometric data with continuous coverage across parts of six states, preliminary interpretations, examples of geologic mapping applications, and discussion of newly discovered magnetic anomalies and follow-up investigations.