Cyanobacterial harmful algal blooms (cyanoHABs) and associated cyanotoxins are a concern for inland waters. Due to the extensive spatial coverage and frequent availability of satellite images, multispectral remote sensing tools demonstrate utility for monitoring these blooms. The next frontier for remote sensing of cyanoHABs in inland waters is hyperspectral data. Recent and upcoming hyperspectral satellite missions using narrow wavelength imaging spectrometers could have a major impact on advancing our ability to detect, quantify, and characterize cyanobacterial blooms. This study compares multispectral and hyperspectral remote sensing capabilities and processing tools for monitoring cyanoHAB dynamics. We evaluated the temporal trends of cyanoHABs in Clear Lake, California, a hypereutrophic lake with diverse cyanobacteria genera based on 38 sampling events over a five-year monitoring period (2019–2023). We validated the Sentinel-3 Ocean and Land Color Instrument (multispectral) Cyanobacteria Index algorithm for Clear Lake using in situ cyanobacteria measurements, which complemented our field-based evaluation of cyanobacteria trends in Clear Lake. We then demonstrate the advantages of hyperspectral data from both in situ spectroradiometer measurements and full-lake hyperspectral satellite images. We apply the Spectral Mixture Analysis for Surveillance of HABs (SMASH) workflow, a Multiple Endmember Spectral Mixture Analysis (MESMA) algorithm, to the hyperspectral images to assess the potential of satellite imaging spectrometer data to identify cyanobacteria genera – the first study to test this tool outside its original study sites. We developed a Clear Lake-specific cyanobacteria spectral library using our field spectroradiometer measurements to improve SMASH performance in Clear Lake, which supports the continued development of this tool.