Freshwater mussels are critical to the health of freshwater systems, but their populations are declining dramatically throughout the world. The limited resources available for freshwater mussel conservation necessitates the geographic prioritization of conservation-related actions. However, lack of knowledge about freshwater mussel spatial distributions hinders decision making in this context. In this study, we assessed the distribution of twelve native freshwater mussel species across six Northeastern states (Connecticut, Rhode Island, Massachusetts, Vermont, New Hampshire, and Maine) in the United States using data collected from lentic and lotic environments by eight state agencies. We first modeled individual distributions using a maximum entropy (MaxEnt) model and then compiled distribution models to assess the distribution of freshwater mussel species richness. We also determined geographic prioritization for three conservation-related actions: species surveys, land protection, and population restoration of species of high conservation concern. We found that the percent of catchments predicted to have species occurrence (based on a probability threshold) varied across species, with Elliptio complanata (Eastern elliptio) predicted to occur in the greatest percent of available catchments (33.92%) and Alasmidonta heterodon (Dwarf wedgemussel) expected in the smallest percent (5.30%). The predicted overall species richness within our modeled catchments ranged from zero to all twelve species, with an average of two species per catchment. Although conservation priorities vary depending on the conservation action of interest, we found some areas of consistent importance including much of Maine and the southern reaches of the Connecticut River. An improved understanding of freshwater mussel distribution in a landscape framework will enable managers to implement more precise and efficient conservation interventions for these essential aquatic species.