Few pristine rivers remain worldwide, as they are among the most anthropogenically modified ecosystems. We suggest the geomorphology, hydrology and ecology of Anthropocene rivers are fundamentally different from historical natural rivers. These changes challenge conventional fisheries management practices, suggesting the tools supporting fisheries management may require expansion so that strategies match the scope and scale of present-day problems. We believe that resilience-thinking concepts offer substantial benefits for fisheries managers in Anthropocene rivers. When viewing resilience as a property of an ecosystem, the focus should be increasing the capacity of the system to self-organise and adapt to withstand regime shifts from internal and external disturbances. As an approach, a resilience-based perspective favours managing for sustainability and stewardship of fisheries by placing an emphasis on enhancing the capacity of complex systems to cope with dynamic change. Three case studies presented herein use resilience thinking to highlight challenges and opportunities for fisheries management in Anthropocene rivers from Europe, North America and Australia. Ultimately, a resilience approach to fisheries management emphasises increasing the ecological, institutional and societal capacities to deal with change, whether those changes be hydroclimatic, geomorphic, biological or social, to sustain desirable subsistence, recreational and commercial fisheries.