Remote sensing can provide reliable information on river depths and this approach might be particularly valuable in areas that are difficult to survey via conventional field methods. In this study, we assessed the potential to map the bathymetry of an inaccessible proglacial river in Alaska from both aerial orthophotos and a multispectral satellite image. In addition, we evaluated a variety of depth retrieval algorithms with different input data requirements, including some methods that require field measurements of water depth for calibration and other techniques that can be applied even when such field data are not available. These approaches might enable more efficient use of remote sensing methods by resource management agencies. Our results suggest that bathymetric mapping along the turquoise-colored river we examined was not only feasible but highly accurate ( R² up to 0.94) for both types of image data. Algorithms that use paired observations of depth and reflectance to train depth retrieval models were the most accurate, with errors on the order of 15%–20% and little or no bias. Alternative techniques based on hydraulic and statistical concepts also led to strong agreement between predicted and observed depths but were more susceptible to systematic biases toward under- or over-estimation of depth. In contrast to clear-flowing streams, bathymetric mapping in this environment was enabled by a direct relationship between the depth and brightness of the water due to scattering by suspended sediment. In selecting an appropriate depth retrieval method, a compromise might need to be reached between the level of field effort invested and the accuracy of the resulting image-derived bathymetry. Standalone software for implementing these techniques is freely available.