Seismic design criteria for new buildings in the United States have historically focused on life safety performance objectives through minimizing the potential for structural collapse. Development of design criteria to meet this performance objective has evolved over time, leading to the current, risk-targeted maximum considered earthquake (MCE_R) design basis. Corresponding MCE_R seismic design loads incorporate the full range of probabilistic ground motion hazard information available from U.S. Geological Survey National Seismic Hazard Models, as well as a representation of the uncertainty in structural collapse capacity. Despite these considerable advances in structural design criteria, guidelines for geotechnical hazards such as liquefaction-induced damage, which continue to be based on uniform ground-shaking hazard (i.e., MCE ground motions), are not well-connected with risk-based, collapse prevention performance objectives. This study, undertaken as part of Building Seismic Safety Council efforts to update recommended seismic provisions through the National Earthquake Hazards Reduction Program, presents probabilistic, liquefaction-targeted design objectives and corresponding ground motion parameters, with a focus on improving consistency in first-level screening criteria for liquefaction hazard assessment. This study identifies a potential maximum acceptable annualized probability of liquefaction triggering (P_L,max) of 2.5% in 50 years, above which liquefaction consequences and potential mitigation measures would be considered. The P_L,max-based design basis is calibrated to effective probabilistic liquefaction hazard levels obtained in practice using current MCE peak ground accelerations, and could be implemented via a new liquefaction-targeted maximum considered earthquake (MCE_L) peak ground acceleration (PGA_L). The proposed PGA_L is derived from probabilistic liquefaction hazard curves and includes uncertainties inherent to liquefaction hazard modeling. The potential design effects of the proposed PGA_L are demonstrated via comparison with current MCE PGA levels, effects on first-level liquefaction screening analyses, and improvements in the consistency of P_L,max levels across the United States, and for a wide range of site conditions.