This paper is a review of the sequence of events within the Great Lakes and their drainage to provide a basis for interpreting probable cause-and-effect relations between events of settlement and changes in the ecosystem of the Great Lakes. Possibilities of restoration of the lakes are discussed. A plan to do so must include (1) improvement of land uses in the drainage basin, (2) elimination of sources of physical, chemical, and biological pollution entering the lakes, and (3) restoration of favorable and productive fish populations.