This report summarizes major findings about water quality in the upper Colorado River basin that emerged from an assessment conducted between 1996 and 1998 by the U.S. Geological Survey (USGS) National Water Quality Assessment (NAWQA) Program. Water quality is discussed in terms of local and regional issues and compared to conditions found in all 36 NAWQA study areas assessed to date. Findings are also explained in the context of selected national benchmarks, such as those for drinking water quality and the protection of aquatic organisms.