The Medfra quadrangle in west-central Alaska was investigated by a multidisciplinary team of geoscientists to assess its mineral resources. This Circular is intended to serve as a guide to a folio of 13 separate Open-File Reports covering various aspects of these investigations, including geology, bedrock and stream-sediment geochemistry, potassium-argon dating, Landsat imagery, mineral occurrences, aeromagnetic interpretation, and mineral-resource assessment. This Circular presents a complete reference list of these reports and a summary of the important results of each of the investigations.