High resolution aeromagnetic survey data flown at 250 m above the terrain and 250 m line spacing over the Santa Cruz Valley and the surrounding Tumacacori, Patagonia, and Santa Rita Mountains has been interpreted by correlation of the magnetic anomaly field and various derivative maps with geologic maps. Measurements of in-situ magnetic properties of several of the map units determined whether or not mapped lithologies were responsible for observed anomalies. Correlation of the magnetic anomaly field with mapped geology shows that numerous map units of volcanic and intrusive rocks from Jurassic Middle Tertiary in age are reversely polarized, some of which have not been previously reported. Trends derived from the magnetic anomaly data correlate closely with structures from major tectonic events in the geologic history of the area including Triassic-Jurassic crustal accretion and magmatism, Laramide magmatism and tectonism, northeast-southwest Mid-Tertiary extension, and east-west Basin and Range extension. Application of two textural measures to the magnetic anomaly data, number of peaks and troughs per km (a measure of roughness) and Euclidean length per km (a measure of amplitude), delineated areas of consistent magnetic anomaly texture. These measures were successful at the delineation of areas of consistent magnetic lithology both on the surface and in the subsurface beneath basin fill. Several areas of basement prospective for mineral resources beneath basin fill were identified.