The U.S. Geological Survey, in support of the U.S. Department of Energy, Office of Repository Development, collects, compiles, and summarizes hydrologic data in the Yucca Mountain region of southern Nevada and eastern California. These data are collected to allow assessments of ground-water resources during activities to determine the potential suitability or development of Yucca Mountain for storing high-level nuclear waste. Data on ground-water levels at 35 boreholes and 1 fissure (Devils Hole), ground-water discharge at 5 springs, both ground-water levels and discharge at 1 flowing borehole, and total reported ground-water withdrawals within Crater Flat, Jackass Flats, Mercury Valley, and the Amargosa Desert are tabulated from January through December 2004. Also tabulated are ground-water levels, discharges, and withdrawals collected by other agencies (or collected as part of other programs) and data revised from those previously published at monitoring sites. Historical data on water levels, discharges, and withdrawals are presented graphically to indicate variations through time. A statistical summary of ground-water levels at seven boreholes in Jackass Flats is presented for the period 1992-2004 to indicate potential effects of ground-water withdrawals associated with U.S. Department of Energy activities near Yucca Mountain. The statistical summary includes the annual number of measurements, maximum, minimum, and median water-level altitudes, and average deviation of measured water-level altitudes compared to the 1992-93 baseline period. At six boreholes in Jackass Flats, median water levels for 2004 were slightly higher (0.3-2.7 feet) than their median water levels for 1992-93. At one borehole in Jackass Flats, median water level for 2004 equaled the median water level for 1992-93.