Two separate weather systems produced storms resulting in more than 11 inches of rain in parts of Lake County, Ohio, on July 27-28, 2006. As a result of the storms and ensuing flooding caused by the weather systems, the counties of Lake, Geauga, and Ashtabula were declared Federal and State disaster areas, with damages estimated at $30 million and one fatality in Lake County. About 600 people were evacuated in Lake County. The U.S. Geological Survey streamflow-gaging station at Grand River near Painesville, Ohio (station 04212100), had a record peak stage of 19.35 feet (elevation, 614.94 feet), with a record peak streamflow of 35,000 cubic feet per second, and an estimated recurrence interval of approximately 500 years. This report describes the meteorological factors that resulted in severe flooding on the Grand River near Painesville from July 27 to July 31, 2006, and addresses the damages caused by the storms and flooding. Peak-stage, peak-streamflow, and recurrence-interval data are reported for the Grand River near Painesville. A plot of high-water marks is also presented for the Grand River in a reach that includes the City of Painesville, Painesville Township, the Village of Fairport Harbor, and the Village of Grand River.