This open-file report presents WDXRF major-element chemical data for late Pliocene to Holocene volcanic rocks collected from Lassen Volcanic National Park and vicinity, California. Data for Rb, Sr, Ba, Y, Zr, Nb, Ni, Cr, Zn and Cu obtained by EDXRF are included for many samples. Data are presented in an EXCEL spreadsheet and are keyed to rock units as displayed on the Geologic Map of Lassen Volcanic National Park and vicinity (Clynne and Muffler, in press). Location of the samples is given in latitude and longitude in degrees and decimal minutes and in decimal degrees.