Johnson County is the fastest growing county in Kansas, with a population of about 560,000 people in 2012. Urban growth and development can have substantial effects on water quality, and streams in Johnson County are affected by nonpoint-source pollutants from stormwater runoff and point-source discharges such as municipal wastewater effluent. Understanding of current (2014) water-quality conditions and the effects of urbanization is critical for the protection and remediation of aquatic resources in Johnson County, Kansas and downstream reaches located elsewhere. The Indian Creek Basin is 194 square kilometers and includes parts of Johnson County, Kansas and Jackson County, Missouri. Approximately 86 percent of the Indian Creek Basin is located in Johnson County, Kansas. The U.S. Geological Survey, in cooperation with Johnson County Wastewater, operated a series of six continuous real-time water-quality monitoring stations in the Indian Creek Basin during June 2011 through May 2013; one of these sites has been operating since February 2004. Five monitoring sites were located on Indian Creek and one site was located on Tomahawk Creek. The purpose of this report is to document regression models that establish relations between continuously measured water-quality properties and discretely collected water-quality constituents. Continuously measured water-quality properties include streamflow, specific conductance, pH, water temperature, dissolved oxygen, turbidity, and nitrate. Discrete water-quality samples were collected during June 2011 through May 2013 at five new sites and June 2004 through May 2013 at a long-term site and analyzed for sediment, nutrients, bacteria, and other water-quality constituents. Regression models were developed to establish relations between discretely sampled constituent concentrations and continuously measured physical properties to estimate concentrations of those constituents of interest that are not easily measured in real time because of limitations in sensor technology and fiscal constraints. Regression models for 28 water-quality constituents were developed and documented. The water-quality information in this report is important to Johnson County Wastewater because it allows the concentrations of many potential pollutants of interest, including nutrients and sediment, to be estimated in real time and characterized during conditions and time scales that would not be possible otherwise.