This report describes Geographic Information System data sets of ground-water levels, unsaturated-zone thickness, and regolith thickness in the Pequea and Mill Creek watersheds, a 210-square-mile area in Lancaster and Chester Counties, Pa. The data sets, which represent hydrogeologic interpretations, were developed by the use of ARC/INFO software during 1990-93 by the U.S. Geological Survey, in cooperation with the Pennsylvania Department of Environmental Resources. The U.S. Environmental Protection Agency proposes to use these interpretive data sets, and those from other sources, to aid in the assessment of ground-water vulnerability to pesticides in the Pequea and Mill Creek watersheds.