Ground-water budgets are presented in this report for 14 regionally extensive aquifer systems; pumpage from 11 of these systems provided from 40 to 50 percent of the ground water withdrawn in the United States during the 1970's and 1980's. The budgets are based on simulation results from computer-based models developed as part of the Regional Aquifer-System Analysis Program of the U.S. Geological Survey. Most of the models cover large areas (30,000-300,000 square miles) and generally are constructed with coarse-mesh finite-difference grids designed to simulate regional ground-water flow. The groundwater budgets derived from these models generally do not include local flow that enters and exits regional aquifers after traveling only a few miles or flow in overlying surficial aquifers. Budgets are presented for predevelopment and recent pumping conditions for most of the aquifer systems.